Product Details
- Hardcover: 273 pages
- Publisher: Birkhauser; 1 edition (February 14, 2005)
- Language: English
- ISBN: 3764359250
Book Description:
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science.
Contents
List of contributors
Preface
I. Basic research
Indirect antimicrobial effects
Kazuhiro Tateda, Theodore J. Standiford and Keizo Yamaguchi
Effects of antibiotics on Pseudomonas aeruginosa virulence factors
and quorum-sensing system
Anti-inflammatory effects
Michael J. Parnham
Antibiotics, inflammation and its resolution: an overview
Charles Feldman and Ronald Anderson
The cytoprotective interactions of antibiotics with human ciliated
airway epithelium
Jun-ichi Kadota
Chemotaxis
Hajime Takizawa
Cytokines
Marie-Thérèse Labro
Antibacterial agents and the oxidative burst
Jun-ichi Kadota
Immune system
Mucoregulatory effects
Kiyoshi Takeyama
Macrolides and mucus production
Jun Tamaoki
Ion channel regulation
II. Clinical results
Arata Azuma and Shoji Kudoh
The use of macrolides for treatment of diffuse panbronchiolitis
Adam Jaffé and Andrew Bush
Macrolides in cystic fibrosis
Kazuhiko Takeuchi, Yuichi Majima and Qutayba Hamid
Macrolides and upper airway/sinus disease
Rose Jung, Mark H. Gotfried and Larry H. Danziger
Benefits of macrolides in the treatment of asthma
Arata Azuma
Roles of antibiotics in treatment of lung injury
Keiichi Mikasa, Kei Kasahara and Eiji Kita
Antibiotics and cancer, arthritis and IBD
Bruce K. Rubin, Markus O. Henke and Axel Dalhoff
Anti-inflammatory properties of antibiotics other than macrolides
Index
