Antimicrobial Resistance: Problem Pathogens and Clinical Countermeasures (Infectious Disease and Therapy)
by Jr., Robert C. Owens (Editor), Ebbing Lautenbach (Editor)
Product Details
* Hardcover: 520 pages
* Publisher: Informa Healthcare; 1 edition (December 22, 2007)
* Language: English
* ISBN-10: 0824729412
Book Description
This publication provides a state-of-the-art overview of key issues related to antimicrobial resistance, including a focus on key pathogens causing common healthcare-associated and community-acquired infections. The epidemiology and therapeutic considerations of these antimicrobial resistant organisms are discussed, as well as the clinical and health economic impact of infections caused by them. This progressive reference also provides a dedicated section covering the clinical programmatic strategies used to minimize the growing antimicrobial resistance problem, including practical information related to interventional concepts and their implementation. In addition to antimicrobial resistance in the context of traditionally discussed problematic bacterial pathogens, emerging data related to clinically important fungal pathogens and Clostridium difficile are also covered.
Contents
Foreword Robert C. Moellering, Jr. v
Preface ix
Contributors xv
Part I: Resistance Concerns for the Practicing Clinician:
General Considerations
1. The Attributable Costs of Resistant Infections in Hospital Settings:
Economic Theory and Application 1
R. Douglas Scott II and Rebecca R. Roberts
2. Benchmarking: Its Utility in the Fight Against Antibacterial Resistance 25
Sujata M. Bhavnani and Glenn S. Tillotson
3. Antibiotic Resistance: Opportunity or Obstacle for the
Pharmaceutical Industry? 39
Glenn S. Tillotson
4. Understanding Studies of Resistant Organisms: Focus on
Epidemiological Methods 61
Ebbing Lautenbach
Part II: Contemporary Antimicrobial Resistance Issues: Gram-Positive,
Gram-Negative, and Miscellaneous Pathogens
5. Staphylococcus aureus: Resistance Update and Treatment Options 75
Pamela A. Moise and George Sakoulas
6. Enterococci: Resistance Update and Treatment Options 89
Peter K. Linden
7. Streptococcus pneumoniae: Resistance Update and Treatment Options 111
Nicole Akar, William R. Bishai, and Sanjay K. Jain
8. Acinetobacter Species: Resistance Update and Treatment Options 125
Lisa L. Maragakis and Trish M. Perl
9. Pseudomonas aeruginosa: An Understanding of Resistance Issues 149
Karen Lolans, Maria Virginia Villegas, and John P. Quinn
10. Problematic Beta-Lactamases: An Update 169
Marion S. Helfand and Louis B. Rice
11. Clostridium difficile-Infection: Overview and Update with a Focus on Antimicrobial
Resistance as a Risk Factor 183
Robert C. Owens, Jr., August J. Valenti, and Mark H. Wilcox
12. Emerging Resistance Among Candida Species: Trends and Treatment
Considerations for Candidemia 219
Ingi Lee and Theoklis Zaoutis
Part III: Interventional Strategies to Combat Resistance
13. Early Appropriate Empiric Therapy and Antimicrobial De-Escalation 231
James M. Hollands, Scott T. Micek, Peggy S. McKinnon, and Marin H. Kollef
14. Antimicrobial Cycling Programs 251
Bernard C. Camins and Victoria J. Fraser
15. Antimicrobial Stewardship: Rationale for and Practical Considerations of
Programmatic Institutional Efforts to Optimize Antimicrobial Use 261
Robert C. Owens, Jr.
16. Computer-Assisted Programs to Optimize Antimicrobial Use 301
Stanley L. Pestotnik and Jonathan B. Olson
17. Practical Application of Pharmacodynamic Principles to Optimize Therapy and
Treat Resistant Organisms: A Focus on Beta-Lactam Antibiotics 317
Thomas P. Lodise, Ben M. Lomaestro, and George L. Drusano
18. Shorter Course Antibiotic Therapy (SCAT): Principles,
Current Data, and Caveats 337
Donald E. Craven, Daniel P. McQuillen, Winnie W. Ooi, George A. Jacoby,
Efren L. Rael, and Kathleen Steger Craven
19. Impact of Guidelines on Antimicrobial Treatment of Respiratory
Tract Infections 371
Thomas M. File
20. The Impact of Hospital Epidemiology on the Management and Control of
Antimicrobial Resistance: Issues and Controversies 397
August J. Valenti
21. Combination Antimicrobial Therapy for Gram-Negative Infections:
What Is The Evidence? 433
Nasia Safdar and Cybele L. Abad
22. Antibiotic Resistance: Modern Principles and Management Strategies to Optimize
Outpatient Use of Antibiotics 461
Sharon B. Meropol and Joshua P. Metlay
